Ontology highlight
ABSTRACT:
SUBMITTER: Almon RR
PROVIDER: S-EPMC3516129 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Almon Richard R RR Dubois Debra C DC Sukumaran Siddharth S Wang Xi X Xue Bai B Nie Jing J Jusko William J WJ
Gene regulation and systems biology 20121128
Effects of high fat diet (HFD) on obesity and, subsequently, on diabetes are highly variable and modulated by genetics in both humans and rodents. In this report, we characterized the response of Goto-Kakizaki (GK) rats, a spontaneous polygenic model for lean diabetes and healthy Wistar-Kyoto (WKY) controls, to high fat feeding from weaning to 20 weeks of age. Animals fed either normal diet or HFD were sacrificed at 4, 8, 12, 16 and 20 weeks of age and a wide array of physiological measurements ...[more]