Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC3516853 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Liu C C Kawedia J D JD Cheng C C Pei D D Fernandez C A CA Cai X X Crews K R KR Kaste S C SC Panetta J C JC Bowman W P WP Jeha S S Sandlund J T JT Evans W E WE Pui C-H CH Relling M V MV
Leukemia 20120409 11
Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We studied allergic reactions and serum antibodies to E. coli asparaginase (Elspar) in 410 children treated on St. Jude Total XV protocol for acute lymphoblastic leukemia. Of 169 patients (41.2%) with clinical allergy, 147 (87.0%) were positive for anti-Elspar antibody. Of 241 patients without allergy, 89 (36.9%) had detectable antibody. Allergies ...[more]