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A rigid bicyclic platform for the generation of conformationally locked neuraminidase inhibitors.

ABSTRACT: Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.

SUBMITTER: Brant MG

PROVIDER: S-EPMC3516865 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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A rigid bicyclic platform for the generation of conformationally locked neuraminidase inhibitors.

Brant Michael G MG Wulff Jeremy E JE

Organic letters 20121126 23

Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported. ...[more]

PMID: 23181823

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