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Structural determination of NSC 670224, synthesis of analogues and biological evaluation.

ABSTRACT: Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.

SUBMITTER: Zuckerman NB

PROVIDER: S-EPMC3516922 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Structural determination of NSC 670224, synthesis of analogues and biological evaluation.

Zuckerman Nathaniel B NB Myers Andrew S AS Quan Tiffani K TK Bray Walter M WM Lokey R Scott RS Hartzog Grant A GA Konopelski Joseph P JP

ChemMedChem 20120229 5

Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated. ...[more]

PMID: 22378491

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