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A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

ABSTRACT: Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.

SUBMITTER: Hayakawa M 

PROVIDER: S-EPMC3517015 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Hayakawa Masahiko M   Toda Narihiro N   Carrillo Nancy N   Thornburg Natalie J NJ   Crowe James E JE   Barbas Carlos F CF  

Chembiochem : a European journal of chemical biology 20120910 15

Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology. ...[more]

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