Ontology highlight
ABSTRACT:
SUBMITTER: Ene CI
PROVIDER: S-EPMC3517524 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ene Chibawanye I CI Ene Chibawanye I CI Edwards Lincoln L Riddick Gregory G Baysan Mehmet M Woolard Kevin K Kotliarova Svetlana S Lai Chen C Belova Galina G Cam Maggie M Walling Jennifer J Zhou Ming M Stevenson Holly H Kim Hong Sug HS Killian Keith K Veenstra Timothy T Bailey Rolanda R Song Hua H Zhang Wei W Fine Howard A HA
PloS one 20121207 12
Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes. Malignant transformation is associated with aberrant accumulation of repressive histone modifications, such as polycomb mediated histone 3 lysine 27 (H3K27me3) resulting in a histone methylation mediated block to differentiation. The relevance, however, of histone demethylases in cancer remains less clear. We report that JMJD ...[more]