Ontology highlight
ABSTRACT:
SUBMITTER: Scheibner KA
PROVIDER: S-EPMC3517579 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121207 12
MicroRNAs (miRs) play major roles in normal hematopoietic differentiation and hematopoietic malignancies. In this work, we report that miR-27a, and its coordinately expressed cluster (miR-23a∼miR-27a∼miR-24-2), was down-regulated in acute leukemia cell lines and primary samples compared to hematopoietic stem-progenitor cells (HSPCs). Decreased miR-23a cluster expression in some acute leukemia cell lines was mediated by c-MYC. Replacement of miR-27a in acute leukemia cell lines inhibited cell gro ...[more]