Ontology highlight
ABSTRACT:
SUBMITTER: Weber A
PROVIDER: S-EPMC3518178 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Weber Axel A Taube Sylvia S Zur Stadt Udo U Horstmann Martin M Krohn Knut K Bradtke Jutta J Teigler-Schlegel Andrea A Leiblein Sabine S Christiansen Holger H
Experimental hematology & oncology 20121109 1
The amplification of putative oncogenes is a common finding within the genome of various cancer types. Identification and further targeting of specific junction sites within the sequence of genomic amplicons (amplicon fusion sites, AFS) by PCR (AFS-PCR) is suitable for quantification of minimal residual disease (MRD). This approach has recently been developed and described for MYCN amplified neuroblastomas. To compare AFS-PCR directly to routinely used MRD diagnostic strategies, we mapped the am ...[more]