Ontology highlight
ABSTRACT:
SUBMITTER: Trueman SF
PROVIDER: S-EPMC3518225 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Trueman Steven F SF Mandon Elisabet C EC Gilmore Reid R
The Journal of cell biology 20121201 6
A critical event in protein translocation across the endoplasmic reticulum is the structural transition between the closed and open conformations of Sec61, the eukaryotic translocation channel. Channel opening allows signal sequence insertion into a gap between the N- and C-terminal halves of Sec61. We have identified a gating motif that regulates the transition between the closed and open channel conformations. Polar amino acid substitutions in the gating motif cause a gain-of-function phenotyp ...[more]