Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC3518281 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Wu Juan J Zhang Xian X Zhang Ling L Wu Ching-Yuan CY Rezaeian Abdol Hossein AH Chan Chia-Hsin CH Li Ju-Mei JM Wang Jing J Gao Yuan Y Han Fei F Jeong Yun Seong YS Yuan Xiandao X Khanna Kum Kum KK Jin Jianping J Zeng Yi-Xin YX Lin Hui-Kuan HK
Molecular cell 20120329 3
The Mre11/Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for activation. However, it remains to be established how the MRN complex regulates ATM recruitment to the DNA foci during DNA double-strand breaks (DSBs). Here we show that Skp2 E3 ligase is a key component for the MRN complex-mediated ATM activation in response to DSBs. Skp2 interacts with NBS1 and triggers K63-linked ubiquitination of NBS1 upon DSBs, which is critical fo ...[more]