Ontology highlight
ABSTRACT:
SUBMITTER: Fang R
PROVIDER: S-EPMC3518444 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20100701 2
Dynamic histone H3K4 methylation is an important epigenetic component of transcriptional regulation. However, most of our current understanding of this histone mark is confined to the regulation of transcriptional initiation. We now show that human LSD2/KDM1b/AOF1, the human homolog of LSD1, is an H3K4me1/2 demethylase that specifically regulates histone H3K4 methylation within intragenic regions of its target genes. Genome-wide mapping reveals that LSD2 associates predominantly with the gene bo ...[more]