Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC3518573 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Sun Xiangqing X Vengoechea Jaime J Elston Robert R Chen Yanwen Y Amos Christopher I CI Armstrong Georgina G Bernstein Jonine L JL Claus Elizabeth E Davis Faith F Houlston Richard S RS Il'yasova Dora D Jenkins Robert B RB Johansen Christoffer C Lai Rose R Lau Ching C CC Liu Yanhong Y McCarthy Bridget J BJ Olson Sara H SH Sadetzki Siegal S Schildkraut Joellen J Shete Sanjay S Yu Robert R Vick Nicholas A NA Merrell Ryan R Wrensch Margaret M Yang Ping P Melin Beatrice B Bondy Melissa L ML Barnholtz-Sloan Jill S JS
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120907 12
<h4>Background</h4>We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.<h4>Methods</h4>First, we fit segregation models by formulating the likelihood for a person to have a bivariate phenotype, affection status and age of onset, along with other covariates, and from these we estimate population trait allele frequencies and penetrance ...[more]