Ontology highlight
ABSTRACT:
SUBMITTER: Johnson JE
PROVIDER: S-EPMC3518761 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Johnson James E JE Reyes Francis E FE Polaski Jacob T JT Batey Robert T RT
Nature 20121014 7427
Structures of riboswitch receptor domains bound to their effector have shown how messenger RNAs recognize diverse small molecules, but mechanistic details linking the structures to the regulation of gene expression remain elusive. To address this, here we solve crystal structures of two different classes of cobalamin (vitamin B(12))-binding riboswitches that include the structural switch of the downstream regulatory domain. These classes share a common cobalamin-binding core, but use distinct pe ...[more]