Ontology highlight
ABSTRACT:
SUBMITTER: Skelding KA
PROVIDER: S-EPMC3519412 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Skelding Kathryn A KA Spratt Neil J NJ Fluechter Lisa L Dickson Phillip W PW Rostas John A P JA
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120829 12
Different brain regions exhibit differing sensitivities to ischemia/excitotoxicity. Whether these differences are due to perfusion or intrinsic factors has not been established. Herein, we found no apparent association between sensitivity to ischemia/excitotoxicity and the level of expression or basal phosphorylation of calcium/calmodulin-stimulated protein kinase II (αCaMKII) or glutamate receptors. However, we demonstrated significant differences in CaMKII-mediated responses after ischemia/exc ...[more]