Ontology highlight
ABSTRACT:
SUBMITTER: Leljak Levanic D
PROVIDER: S-EPMC3519589 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Leljak Levanić Dunja D Horvat Tomislav T Martinčić Jelena J Bauer Nataša N
PloS one 20121210 12
BPM1 belongs to the MATH-BTB family of proteins, which act as substrate-binding adaptors for the Cullin3-based E3 ubiquitin ligase. MATH-BTB proteins associate with Cullin3 via the BTB domain and with the substrate protein via the MATH domain. Few BPM1-interacting proteins with different functions are recognized, however, specific roles of BPM1, depending on its cellular localization have not been studied so far. Here, we found a novel bipartite nuclear localization signal at the C-terminus of t ...[more]