Ontology highlight
ABSTRACT:
SUBMITTER: Voordeckers K
PROVIDER: S-EPMC3519909 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Voordeckers Karin K Brown Chris A CA Vanneste Kevin K van der Zande Elisa E Voet Arnout A Maere Steven S Verstrepen Kevin J KJ
PLoS biology 20121211 12
Gene duplications are believed to facilitate evolutionary innovation. However, the mechanisms shaping the fate of duplicated genes remain heavily debated because the molecular processes and evolutionary forces involved are difficult to reconstruct. Here, we study a large family of fungal glucosidase genes that underwent several duplication events. We reconstruct all key ancestral enzymes and show that the very first preduplication enzyme was primarily active on maltose-like substrates, with trac ...[more]