Ontology highlight
ABSTRACT:
SUBMITTER: Chmielewski JP
PROVIDER: S-EPMC3519945 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Chmielewski Jeffrey P JP Henderson Laura L Smith Charlotte M CM Christensen Tim W TW
Chromosoma 20120920 6
The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, and a number of disease states. During cell proliferation, replication of DNA represents an ongoing challenge for chromosome packaging as DNA must be unpackaged for replication and then faithfully repackaged. An integral member of the DNA replication machinery is the GINS compl ...[more]