Ontology highlight
ABSTRACT:
SUBMITTER: Duka A
PROVIDER: S-EPMC3520517 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Duka Adelina A Fotakis Panagiotis P Georgiadou Dimitra D Kateifides Andreas A Tzavlaki Kalliopi K von Eckardstein Leonard L Stratikos Efstratios E Kardassis Dimitris D Zannis Vassilis I VI
Journal of lipid research 20121106 1
The objective of this study was to establish the role of apoA-IV, ABCA1, and LCAT in the biogenesis of apoA-IV-containing HDL (HDL-A-IV) using different mouse models. Adenovirus-mediated gene transfer of apoA-IV in apoA-I(-/-) mice did not change plasma lipid levels. ApoA-IV floated in the HDL2/HDL3 region, promoted the formation of spherical HDL particles as determined by electron microscopy, and generated mostly α- and a few pre-β-like HDL subpopulations. Gene transfer of apoA-IV in apoA-I(-/- ...[more]