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Targeting the TGF? signalling pathway in disease.

ABSTRACT: Many drugs that target transforming growth factor-? (TGF?) signalling have been developed, some of which have reached Phase III clinical trials for a number of disease applications. Preclinical and clinical studies indicate the utility of these agents in fibrosis and oncology, particularly in augmentation of existing cancer therapies, such as radiation and chemotherapy, as well as in tumour vaccines. There are also reports of specialized applications, such as the reduction of vascular symptoms of Marfan syndrome. Here, we consider why the TGF? signalling pathway is a drug target, the potential clinical applications of TGF? inhibition, the issues arising with anti-TGF? therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens.

SUBMITTER: Akhurst RJ

PROVIDER: S-EPMC3520610 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Targeting the TGFβ signalling pathway in disease.

Akhurst Rosemary J RJ Hata Akiko A

Nature reviews. Drug discovery 20120924 10

Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed, some of which have reached Phase III clinical trials for a number of disease applications. Preclinical and clinical studies indicate the utility of these agents in fibrosis and oncology, particularly in augmentation of existing cancer therapies, such as radiation and chemotherapy, as well as in tumour vaccines. There are also reports of specialized applications, such as the reduction of vascular symptoms o ...[more]

PMID: 23000686

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