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ABSTRACT: Background
Although 1 in 5 adults will develop heart failure (HF) in their lifetime, data on the effect of plasma omega-6 (n-3) PUFAs on risk of HF are currently sparse.Objectives
We investigated whether plasma phospholipid omega-6 concentrations are associated with risk of HF in US male physicians. In a secondary analysis, we evaluated whether such an association differs between HF with and without previous myocardial infarction (MI).Design
With the use of a nested case-control design, this ancillary study comprised 788 cases and 788 matched controls from the Physicians' Health Study. Plasma omega-6 PUFAs were measured by using gas chromatography.Results
The mean age of subjects was 58.7 y with a mean follow-up time of 17.1 y. We did not show any evidence of a statistically significant relation between total omega-6 PUFAs and HF [OR (95% CI): 1.00; 0.85 (0.63, 1.14); 0.84 (0.63, 1.13); and 0.87 (0.63, 1.20) across consecutive quartiles of omega-6 PUFAs; P-linear trend = 0.39]. Results were similar for HF with and without previous MI.Conclusion
Our data showed no significant association between total plasma omega-6 PUFAs and risk of developing HF.
SUBMITTER: Petrone AB
PROVIDER: S-EPMC3522140 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Petrone Andrew B AB Weir Natalie N Hanson Naomi Q NQ Glynn Robert R Tsai Michael Y MY Gaziano J Michael JM Djoussé Luc L
The American journal of clinical nutrition 20121128 1
<h4>Background</h4>Although 1 in 5 adults will develop heart failure (HF) in their lifetime, data on the effect of plasma omega-6 (n-3) PUFAs on risk of HF are currently sparse.<h4>Objectives</h4>We investigated whether plasma phospholipid omega-6 concentrations are associated with risk of HF in US male physicians. In a secondary analysis, we evaluated whether such an association differs between HF with and without previous myocardial infarction (MI).<h4>Design</h4>With the use of a nested case- ...[more]