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Sirtuin catalysis and regulation.

ABSTRACT: Sirtuins are a family of NAD(+)-dependent protein deacetylases/deacylases that dynamically regulate transcription, metabolism, and cellular stress response. Their general positive link with improved health span in mammals, potential regulation of pathways mediated by caloric restriction, and growing links to human disease have spurred interest in therapeutics that target their functions. Here, we review the current understanding of the chemistry of catalysis, biological targets, and endogenous regulation of sirtuin activity. We discuss recent efforts to generate small-molecule regulators of sirtuin activity.

SUBMITTER: Feldman JL

PROVIDER: S-EPMC3522242 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Sirtuin catalysis and regulation.

Feldman Jessica L JL Dittenhafer-Reed Kristin E KE Denu John M JM

The Journal of biological chemistry 20121018 51

Sirtuins are a family of NAD(+)-dependent protein deacetylases/deacylases that dynamically regulate transcription, metabolism, and cellular stress response. Their general positive link with improved health span in mammals, potential regulation of pathways mediated by caloric restriction, and growing links to human disease have spurred interest in therapeutics that target their functions. Here, we review the current understanding of the chemistry of catalysis, biological targets, and endogenous r ...[more]

PMID: 23086947

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