Structural basis for sirtuin activity and inhibition.
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ABSTRACT:
SUBMITTER: Yuan H
PROVIDER: S-EPMC3522243 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Structural basis for sirtuin activity and inhibition.
Yuan Hua H Marmorstein Ronen R
The Journal of biological chemistry 20121018 51
Sir2 proteins, or sirtuins, are a family of enzymes that catalyze NAD(+)-dependent deacetylation reactions and can also process ribosyltransferase, demalonylase, and desuccinylase activities. More than 40 crystal structures of sirtuins have been determined, alone or in various liganded forms. These high-resolution architectural details lay the foundation for understanding the molecular mechanisms of catalysis, regulation, substrate specificity, and inhibition of sirtuins. In this minireview, we ...[more]
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