Ontology highlight
ABSTRACT:
SUBMITTER: Kazma R
PROVIDER: S-EPMC3522730 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Kazma Rémi R Mefford Joel A JA Cheng Iona I Plummer Sarah J SJ Levin Albert M AM Rybicki Benjamin A BA Casey Graham G Witte John S JS
PloS one 20121214 12
Prostate cancer is the most frequent and second most lethal cancer in men in the United States. Innate immunity and inflammation may increase the risk of prostate cancer. To determine the role of innate immunity and inflammation in advanced prostate cancer, we investigated the association of 320 single nucleotide polymorphisms, located in 46 genes involved in this pathway, with disease risk using 494 cases with advanced disease and 536 controls from Cleveland, Ohio. Taken together, the whole pat ...[more]