Ontology highlight
ABSTRACT:
SUBMITTER: Sukasem C
PROVIDER: S-EPMC3522814 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Sukasem Chonlaphat C Cressey Tim R TR Prapaithong Pattamawan P Tawon Yardpiroon Y Pasomsub Ekawat E Srichunrusami Chutatip C Jantararoungtong Thawinee T Lallement Marc M Chantratita Wasun W
British journal of clinical pharmacology 20121201 6
<h4>Aims</h4>To investigate the frequency of CYP2B6 polymorphisms and the influence of haplotype structure on plasma efavirenz concentrations in Thai adults with HIV-1 infection.<h4>Methods</h4>Genotyping of nine single nucleotide polymorphisms (SNPs, c.64C>T, c.499C>G, c.516G>T, c.785A>G, c.1375A>G, c.1459C>T, g.3003T>C, g.18492C>T and g.21563C>T) of CYP2B6 were performed using real-time PCR-based allelic discrimination on blood samples from 52 HIV-infected adults who had received an efavirenz- ...[more]