Ontology highlight
ABSTRACT:
SUBMITTER: Ongarora BG
PROVIDER: S-EPMC3523363 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ongarora Benson G BG Fontenot Krystal R KR Hu Xiaoke X Sehgal Inder I Satyanarayana-Jois Seetharama D SD Vicente M Graça H MG
Journal of medicinal chemistry 20120418 8
Four phthalocyanine (Pc)-peptide conjugates designed to target the epidermal growth factor receptor (EGFR) were synthesized and evaluated in vitro using four cell lines: human carcinoma A431 and HEp2, human colorectal HT-29, and kidney Vero (negative control) cells. Two peptide ligands for EGFR were investigated: EGFR-L1 and -L2, bearing 6 and 13 amino acid residues, respectively. The peptides and Pc-conjugates were shown to bind to EGFR using both theoretical (Autodock) and experimental (SPR) i ...[more]