Ontology highlight
ABSTRACT:
SUBMITTER: Moore AS
PROVIDER: S-EPMC3523391 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Moore A S AS Faisal A A Gonzalez de Castro D D Bavetsias V V Sun C C Atrash B B Valenti M M de Haven Brandon A A Avery S S Mair D D Mirabella F F Swansbury J J Pearson A D J AD Workman P P Blagg J J Raynaud F I FI Eccles S A SA Linardopoulos S S
Leukemia 20120222 7
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD(+) acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has restricted investigations to determine the mechanism of acquired therapeutic resistance, thereby limiting the development of effective treatments. We generated selective FLT3 inhibitor-resistant cells by treating the FLT3-ITD(+) human AML cell line MOLM-13 in vitro with the FLT3-selective inhibitor MLN518, and ...[more]