Ontology highlight
ABSTRACT:
SUBMITTER: Lan Q
PROVIDER: S-EPMC3523557 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Lan Qin Q Zhou Xiaohui X Fan Huimin H Chen Maogen M Wang Julie J Ryffel Bernhard B Brand David D Ramalingam Rajalakshmy R Kiela Pawel R PR Horwitz David A DA Liu Zhongmin Z Zheng Song Guo SG
Journal of molecular cell biology 20120706 6
Interplay between Foxp3(+) regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are not well understood. We report that polyclonal CD4(+)Foxp3(+) Treg cells induced ex vivo with transforming growth factor beta (TGFβ) (iTreg) suppress a lupus-like chronic graft-versus-host disease by preventing the expansion of immunogenic DCs and inducing protective DCs that generate additional recipient CD4(+)Foxp3(+) cells. The protectiv ...[more]