Ontology highlight
ABSTRACT:
SUBMITTER: Kato H
PROVIDER: S-EPMC3523682 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Kato Hidenori H Gruschus James J Ghirlando Rodolfo R Tjandra Nico N Bai Yawen Y
Journal of the American Chemical Society 20091001 42
The N-terminal tail domains (NTDs) of histones play important roles in the formation of higher-order structures of chromatin and the regulation of gene functions. Although the structure of the nucleosome core particle has been determined by X-ray crystallography at near-atomic resolution, the histone tails are not observed in this structure. Here, we demonstrate that large quantities of nucleosome arrays with well-defined DNA positioning can be reconstituted using specific DNA sequences and reco ...[more]