Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
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ABSTRACT:
SUBMITTER: Andersson LS
PROVIDER: S-EPMC3523687 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
Andersson Lisa S LS Larhammar Martin M Memic Fatima F Wootz Hanna H Schwochow Doreen D Rubin Carl-Johan CJ Patra Kalicharan K Arnason Thorvaldur T Wellbring Lisbeth L Hjälm Göran G Imsland Freyja F Petersen Jessica L JL McCue Molly E ME Mickelson James R JR Cothran Gus G Ahituv Nadav N Roepstorff Lars L Mikko Sofia S Vallstedt Anna A Lindgren Gabriella G Andersson Leif L Kullander Klas K
Nature 20120801 7413
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on har ...[more]
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