Ontology highlight
ABSTRACT:
SUBMITTER: Kato HK
PROVIDER: S-EPMC3523713 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Neuron 20121201 5
How are sensory representations in the brain influenced by the state of an animal? Here we use chronic two-photon calcium imaging to explore how wakefulness and experience shape odor representations in the mouse olfactory bulb. Comparing the awake and anesthetized state, we show that wakefulness greatly enhances the activity of inhibitory granule cells and makes principal mitral cell odor responses more sparse and temporally dynamic. In awake mice, brief repeated odor experience leads to a gradu ...[more]