Ontology highlight
ABSTRACT:
SUBMITTER: Shriver MD
PROVIDER: S-EPMC3525270 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Shriver Mark D MD Mei Rui R Parra Esteban J EJ Sonpar Vibhor V Halder Indrani I Tishkoff Sarah A SA Schurr Theodore G TG Zhadanov Sergev I SI Osipova Ludmila P LP Brutsaert Tom D TD Friedlaender Jonathan J Jorde Lynn B LB Watkins W Scott WS Bamshad Michael J MJ Gutierrez Gerardo G Loi Halina H Matsuzaki Hajime H Kittles Rick A RA Argyropoulos George G Fernandez Jose R JR Akey Joshua M JM Jones Keith W KW
Human genomics 20050601 2
Understanding the distribution of human genetic variation is an important foundation for research into the genetics of common diseases. Some of the alleles that modify common disease risk are themselves likely to be common and, thus, amenable to identification using gene-association methods. A problem with this approach is that the large sample sizes required for sufficient statistical power to detect alleles with moderate effect make gene-association studies susceptible to false-positive findin ...[more]