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UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects.

ABSTRACT: Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP gene polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects.Intervention induced a significant decrease in energy intake (-8.6% ± 17.0%) and a significant increase in energy expenditure (7.7% ± 7.4%). As a result, participants experienced a significant decrease in their BMI of -1.8% ± 2.7%. In a multivariate regression analysis, only UCP2 D/I among the selected UCP gene polymorphisms was associated with a change in BMI independent of the effects of gender, age, baseline BMI, changes in energy intake, and expenditure. Further regression analysis revealed that, in contrast to the DD genotype group, the DI+II genotype group showed no significant association between weight loss and change in energy expenditure suggesting this polymorphism altered the effects of this parameter on change in BMI.The study found UCP2 D/I to be associated with change in BMI by altering the effect of change in energy expenditure on change in BMI.

SUBMITTER: Mutombo PB

PROVIDER: S-EPMC3525894 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects.

Mutombo P B PB Yamasaki Masayuki M Shiwaku Kuninori K

Genetic testing and molecular biomarkers 20121026 1

<h4>Aim</h4>Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity. This study aimed at investigating the effects of UCP gene polymorphisms (UCP1 -3826A/G, UCP2A/V, UCP2 I/D, and UCP3 -55C/T) on change in body mass index (BMI) during a lifestyle modification program in Japanese subjects.<h4>Results</h4>Intervention induced a significant decrease in energy intake (-8.6% ± 17.0%) and a significant increase in energy expenditure (7.7% ± 7.4 ...[more]

PMID: 23101559

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Project description:PurposeTo identify demographic, (bio)physical, behavioral, and psychological determinants of successful lifestyle change and program completion by performing a secondary analysis of the intervention arm of a randomized-controlled trial, investigating a preconception lifestyle intervention.MethodsThe 6-month lifestyle intervention consisted of dietary counseling, physical activity, and behavioral modification, and was aimed at 5-10% weight loss. We operationalized successful lifestyle change as successful weight loss (??5% weight/BMI???29 kg/m2), weight loss in kilograms, a reduction in energy intake, and an increase in physical activity during the intervention program. We performed logistic and mixed-effect regression analyses to identify baseline factors that were associated with successful change or program completion.ResultsWomen with higher external eating behavior scores had higher odds of successful weight loss (OR 1.10, 95% CI 1.05-1.16). Women with the previous dietetic support lost 0.94 kg less during the intervention period (95% CI 0.01-1.87 kg). Women with higher self-efficacy reduced energy intake more than women with lower self-efficacy (p?<?0.01). Women with an older partner had an increased energy intake (6 kcal/year older, 95% CI 3-13). A high stage of change towards physical activity was associated with a higher number of daily steps (p?=?0.03). A high stage of change towards weight loss was associated with completion of the intervention (p?=?0.04).ConclusionsDeterminants of lifestyle change and program completion were: higher external eating behavior, not having received previous dietetic support, high stage of change. This knowledge can be used to identify women likely to benefit from lifestyle interventions and develop new interventions for women requiring alternative support.Trial registrationThe LIFEstyle study was registered at the Dutch trial registry (NTR 1530; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1530 ).

Dataset Information

UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects.

Publications

UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects.

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