Ontology highlight
ABSTRACT:
SUBMITTER: Gaur K
PROVIDER: S-EPMC3526160 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Gaur Kriti K Li Jinghong J Wang Dakun D Dutta Pranabananda P Yan Shian-Jang SJ Tsurumi Amy A Land Hartmut H Wu Guan G Li Willis X WX
Human molecular genetics 20121016 2
Birt-Hogg-Dubé syndrome (BHD) is a human cancer disorder caused by mutations in the tumor suppressor gene Folliculin (FLCN) with unknown biological functions. Here, we show that the Drosophila homolog of FLCN, dFLCN (a.k.a. dBHD) localizes to the nucleolus and physically interacts with the 19S proteasomal ATPase, Rpt4, a nucleolar resident and known regulator of rRNA transcription. Downregulation of dFLCN resulted in an increase in nucleolar volume and upregulation of rRNA synthesis, whereas dFL ...[more]