Ontology highlight
ABSTRACT:
SUBMITTER: Leboucher GP
PROVIDER: S-EPMC3526191 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Leboucher Guillaume P GP Tsai Yien Che YC Yang Mei M Shaw Kristin C KC Zhou Ming M Veenstra Timothy D TD Glickman Michael H MH Weissman Allan M AM
Molecular cell 20120628 4
Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential component of the mitochondrial outer membrane fusion apparatus, and the ubiquitin-proteasome system (UPS). JNK phosphorylation of mitofusin 2 in response to cellular stress leads to recruitment of the ubiquitin ligase (E3) Huwe1/Mule/ARF-BP1/HectH9 ...[more]