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Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes.

ABSTRACT: Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV.

SUBMITTER: Erra EO

PROVIDER: S-EPMC3526254 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes.

Erra Elina O EO Askling Helena Hervius HH Yoksan Sutee S Rombo Lars L Riutta Jukka J Vene Sirkka S Lindquist Lars L Vapalahti Olli O Kantele Anu A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20121016 2

Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV. ...[more]

PMID: 23074319

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