Ontology highlight
ABSTRACT:
SUBMITTER: Ponferrada-Marin MI
PROVIDER: S-EPMC3526269 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ponferrada-Marín María Isabel MI Roldán-Arjona Teresa T Ariza Rafael R RR
Nucleic acids research 20121002 22
Active DNA demethylation processes play a critical role in shaping methylation patterns, yet our understanding of the mechanisms involved is still fragmented and incomplete. REPRESSOR OF SILENCING 1 (ROS1) is a prototype member of a family of plant 5-methylcytosine DNA glycosylases that initiate active DNA demethylation through a base excision repair pathway. As ROS1 binds DNA non-specifically, we have critically tested the hypothesis that facilitated diffusion along DNA may contribute to target ...[more]