VLR-based adaptive immunity.
Ontology highlight
ABSTRACT:
SUBMITTER: Boehm T
PROVIDER: S-EPMC3526378 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
VLR-based adaptive immunity.
Boehm Thomas T McCurley Nathanael N Sutoh Yoichi Y Schorpp Michael M Kasahara Masanori M Cooper Max D MD
Annual review of immunology 20120103
Lampreys and hagfish are primitive jawless vertebrates capable of mounting specific immune responses. Lampreys possess different types of lymphocytes, akin to T and B cells of jawed vertebrates, that clonally express somatically diversified antigen receptors termed variable lymphocyte receptors (VLRs), which are composed of tandem arrays of leucine-rich repeats. The VLRs appear to be diversified by a gene conversion mechanism involving lineage-specific cytosine deaminases. VLRA is expressed on t ...[more]
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