Ontology highlight
ABSTRACT:
SUBMITTER: Wilson MJ
PROVIDER: S-EPMC3526380 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wilson Michelle J MJ Liliensiek Sara J SJ Murphy Christopher J CJ Murphy William L WL Nealey Paul F PF
Soft matter 20111026 2
The spacing of peptides away from a hydrogel matrix dramatically impacts their availability and subsequent interactions with cells. Peptides were synthesized with monodisperse poly(ethylene glycol) spacers of different lengths that separate the peptide from the monomeric functionality which reacts during hydrogel polymerization. Specifically, bioactive RGD ligands were conjugated to PEG(5), PEG(11) or PEG(27) spacers via solid phase techniques and then functionalized with an acryloyl end group. ...[more]