Oral doxycycline reduces pterygium lesions; results from a double blind, randomized, placebo controlled clinical trial.

ABSTRACT:

Purpose

To determine whether oral doxycycline treatment reduces pterygium lesions.

Design

Double blind, randomized, placebo controlled clinical trial.

Participants

98 adult patients with primary pterygium.

Methods

Patients were randomly assigned to receive 100 mg oral doxycycline twice a day (49 subjects), or placebo (49 subjects), for 30 days. Photographs of the lesion were taken at the time of recruitment and at the end of the treatment. Follow-up sessions were performed 6 and 12 months post-treatment. Statistical analyses for both continuous and categorical variables were applied. p values of less than 0.05 were considered to indicate statistical significance.

Main outcome measures

The primary endpoint was the change in lesion size after 30 days of tr

SUBMITTER: Rua O 

PROVIDER: S-EPMC3526544 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature