Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.
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ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC3526766 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.
Sun Yi Y Liu Zhancai Z Li Zhaoyong Z Lian Zhengxing Z Zhao Yaofeng Y
Frontiers in immunology 20121220
The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, which is located near the 3' end of the rearranged VH gene, serves as a cryptic recombination signal sequence (3'cRSS) for the VH replacement process. Second, a short stretch of nucleotides located downs ...[more]
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