Ontology highlight
ABSTRACT:
SUBMITTER: Doupe DP
PROVIDER: S-EPMC3527005 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Doupé David P DP Alcolea Maria P MP Roshan Amit A Zhang Gen G Klein Allon M AM Simons Benjamin D BD Jones Philip H PH
Science (New York, N.Y.) 20120719 6098
Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, bu ...[more]