Ontology highlight
ABSTRACT:
SUBMITTER: Basler M
PROVIDER: S-EPMC3527127 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Basler M M Pilhofer M M Henderson G P GP Jensen G J GJ Mekalanos J J JJ
Nature 20120226 7388
Type VI secretion systems are bacterial virulence-associated nanomachines composed of proteins that are evolutionarily related to components of bacteriophage tails. Here we show that protein secretion by the type VI secretion system of Vibrio cholerae requires the action of a dynamic intracellular tubular structure that is structurally and functionally homologous to contractile phage tail sheath. Time-lapse fluorescence light microscopy reveals that sheaths of the type VI secretion system cycle ...[more]