Ontology highlight
ABSTRACT:
SUBMITTER: Hancock DB
PROVIDER: S-EPMC3527213 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hancock Dana B DB Soler Artigas María M Gharib Sina A SA Henry Amanda A Manichaikul Ani A Ramasamy Adaikalavan A Loth Daan W DW Imboden Medea M Koch Beate B McArdle Wendy L WL Smith Albert V AV Smolonska Joanna J Sood Akshay A Tang Wenbo W Wilk Jemma B JB Zhai Guangju G Zhao Jing Hua JH Aschard Hugues H Burkart Kristin M KM Curjuric Ivan I Eijgelsheim Mark M Elliott Paul P Gu Xiangjun X Harris Tamara B TB Janson Christer C Homuth Georg G Hysi Pirro G PG Liu Jason Z JZ Loehr Laura R LR Lohman Kurt K Loos Ruth J F RJ Manning Alisa K AK Marciante Kristin D KD Obeidat Ma'en M Postma Dirkje S DS Aldrich Melinda C MC Brusselle Guy G GG Chen Ting-hsu TH Eiriksdottir Gudny G Franceschini Nora N Heinrich Joachim J Rotter Jerome I JI Wijmenga Cisca C Williams O Dale OD Bentley Amy R AR Hofman Albert A Laurie Cathy C CC Lumley Thomas T Morrison Alanna C AC Joubert Bonnie R BR Rivadeneira Fernando F Couper David J DJ Kritchevsky Stephen B SB Liu Yongmei Y Wjst Matthias M Wain Louise V LV Vonk Judith M JM Uitterlinden André G AG Rochat Thierry T Rich Stephen S SS Psaty Bruce M BM O'Connor George T GT North Kari E KE Mirel Daniel B DB Meibohm Bernd B Launer Lenore J LJ Khaw Kay-Tee KT Hartikainen Anna-Liisa AL Hammond Christopher J CJ Gläser Sven S Marchini Jonathan J Kraft Peter P Wareham Nicholas J NJ Völzke Henry H Stricker Bruno H C BH Spector Timothy D TD Probst-Hensch Nicole M NM Jarvis Deborah D Jarvelin Marjo-Riitta MR Heckbert Susan R SR Gudnason Vilmundur V Boezen H Marike HM Barr R Graham RG Cassano Patricia A PA Strachan David P DP Fornage Myriam M Hall Ian P IP Dupuis Josée J Tobin Martin D MD London Stephanie J SJ
PLoS genetics 20121220 12
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV(1)), and its ratio to forced vital capacity (FEV(1)/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV(1) and FEV(1)/FVC across 19 studies (total N = 50,047). ...[more]