Ontology highlight
ABSTRACT:
SUBMITTER: Wilkins S
PROVIDER: S-EPMC3527294 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wilkins Simon S Zhang Ke Wei KW Mahfuz Istiak I Quantin Renaud R D'Cruz Nancy N Hutson John J Ee Michael M Bagli Darius D Aitken Karen K Fong Fion Nga-Yin FN Ng Patrick Kwok-Shing PK Tsui Stephen Kwok-Wing SK Fung Wendy Yin-Wan WY Banu Tahmina T Thakre Atul A Johar Kaid K Jaureguizar Enrique E Li Long L Cheng Wei W
PLoS genetics 20121220 12
Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying the formation of BEEC remain unclear. TP63, a member of TP53 tumor suppressor gene family, is expressed in bladder urothelium and skin over the external genitalia during mammalian development. It plays a role in bladder development. We have previously shown that p63(-/-) mouse embryos developed a bladder exstrophy phenotype identical to human BEEC. We hypothesised ...[more]