Pathway correlation profile of gene-gene co-expression for identifying pathway perturbation.
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ABSTRACT:
SUBMITTER: Tegge AN
PROVIDER: S-EPMC3527387 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Pathway correlation profile of gene-gene co-expression for identifying pathway perturbation.
Tegge Allison N AN Caldwell Charles W CW Xu Dong D
PloS one 20121220 12
Identifying perturbed or dysregulated pathways is critical to understanding the biological processes that change within an experiment. Previous methods identified important pathways that are significantly enriched among differentially expressed genes; however, these methods cannot account for small, coordinated changes in gene expression that amass across a whole pathway. In order to overcome this limitation, we use microarray gene expression data to identify pathway perturbation based on pathwa ...[more]
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