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The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

ABSTRACT: THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.

SUBMITTER: Castellano-Pozo M

PROVIDER: S-EPMC3527488 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

Castellano-Pozo Maikel M García-Muse Tatiana T Aguilera Andrés A

PloS one 20121220 12

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmental ...[more]

PMID: 23285047

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