Ontology highlight
ABSTRACT:
SUBMITTER: Chadalapaka G
PROVIDER: S-EPMC3527649 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Chadalapaka Gayathri G Jutooru Indira I Sreevalsan Sandeep S Pathi Satya S Kim Kyounghyun K Chen Candy C Crose Lisa L Linardic Corinne C Safe Stephen S
International journal of cancer 20120803 4
Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are highly expressed in rhabdomyosarcoma (RMS) cells. In tissue arrays of RMS tumor cores from 71 patients, 80% of RMS patients expressed high levels of Sp1 protein, whereas low expression of Sp1 was detected in normal muscle tissue. The non-steroidal anti-inflammatory drug (NSAID) tolfenamic acid (TA) inhibited growth and migration of RD and RH30 RMS cell lines and also inhibited tumor growth in vivo using a mouse xenograft (RH30 c ...[more]