Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3527665 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Liu Yingyun Y Schön Arne A Freire Ernesto E
Chemical biology & drug design 20130101 1
As protein/protein interactions usually trigger signalling processes, inhibitors of those interactions must preclude protein binding without eliciting the signalling process themselves. To accomplish those goals, small molecules need to target those protein residues that contribute the most to binding (binding hotspots) without disturbing those residues that initiate signalling processes (allosteric hotspots). The availability of a blueprint identifying binding and allosteric hotspots will signi ...[more]