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Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging.

ABSTRACT: Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine-glycine-aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resistance to nonspecific interactions to normal endothelial cells, and can efficiently detect breast tumor cells through specific cooperative binding of cancer-homing RGD peptides to ?v?3 integrins of cancer cells while its parent polymer A without RGD residues fails to target cancer cells.

SUBMITTER: Zhu S

PROVIDER: S-EPMC3527847 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Highly water-soluble, near-infrared emissive BODIPY polymeric dye bearing RGD peptide residues for cancer imaging.

Zhu Shilei S Zhang Jingtuo J Janjanam Jagadeesh J Bi Jianheng J Vegesna Giri G Tiwari Ashutosh A Luo Fen-Tair FT Wei Jianjun J Liu Haiying H

Analytica chimica acta 20121101

Near-infrared emissive BODIPY polymeric dye bearing cancer-homing cyclic arginine-glycine-aspartic acid (RGD) peptide residues (polymer B) was prepared by post-polymerization functionalization of BODIPY polymeric dye bearing bromo groups through tetra(ethylene glycol) tethered spacers (polymer A) with thiol-functionalized RGD cancer-homing peptide through thioether bonds under a mild basic condition. Polymer B possesses excellent water solubility, good photostability, biocompatibility and resist ...[more]

PMID: 23245906

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