Ontology highlight
ABSTRACT:
SUBMITTER: Davalos V
PROVIDER: S-EPMC3527934 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Dávalos Verónica V Súarez-López Lucía L Castaño Julio J Messent Anthea A Abasolo Ibane I Fernandez Yolanda Y Guerra-Moreno Angel A Espín Eloy E Armengol Manel M Musulen Eva E Ariza Aurelio A Sayós Joan J Arango Diego D Schwartz Simó S
The Journal of biological chemistry 20121024 52
Human SMC2 is part of the condensin complex, which is responsible for tightly packaging replicated genomic DNA prior to segregation into daughter cells. Engagement of the WNT signaling pathway is known to have a mitogenic effect on cells, but relatively little is known about WNT interaction with mitotic structural organizer proteins. In this work, we described the novel transcriptional regulation of SMC2 protein by direct binding of the β-catenin·TCF4 transcription factor to the SMC2 promoter. F ...[more]